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Publications

  • Loh JT*, Teo JKH, Kannan S, Verma C, Andiappan A, Lim HH, Lam KP*. DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit signaling mediator CARD11. Science Signaling. (Manuscript accepted) (*Co-corresponding author)

  • Loh JT, Teo JKH, Kannan S, Verma C, Lim HH, Lam KP. Disrupting Dok3-Card9 interaction with synthetic peptides enhances antifungal effector functions of human neutrophils. Pharmaceutics. (2023). Doi: 10.3390/pharmaceutics15071780

  • Teo KYW, Zhang S, Loh JT, Lai RC, Hey HWD, Lam KP, Lim SK, Toh WS. Mesenchymal stromal cell exosomes mediate M2-like macrophage polarization through CD73/ecto-5’-nucleotidase activity. Pharmaceutics. (2023) doi: 10.3390/pharmaceutics15051489

  • Loh JT* and Lam KP*. Fungal infections: Immune defense, immunotherapies and vaccines. Adv. Drug Deliv. Rev. (2023). doi: 10.1016/j.addr.2023.114775 (*Co-corresponding author)

  • Loh JT and Lam KP. Neutrophils in the pathogenesis of rheumatic diseases. Rheumatol Immunol Res. (2022). doi: 10.2478/rir-2022-0020

  • Loh JT*, Teo JKH, Lam KP*. Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein. Front. Immunol. (2022). doi: 10.3389/fimmu.2022.996637 (*Co-corresponding author)

  • Loh JT, Zhang B, Teo JKH, Lai RC, Choo ABH, Lam KP, Lim SK. Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes. Cytotherapy. (2022) S1465-3249(22)00018-4.doi:10.1016/j.jcyt.2021.12.003.

  • Loh JT, Lee KG, Lee AP, Teo JKH, Lim HL, Kim SSY, Tan AHM, Lam KP. DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils. Cell Death Dis. 12, 1054 (2021). https://doi.org/10.1038/s41419-021-04357-5

  • Wang X, Lin X, Zheng Z, Lu B, Wang J, Tan AHM, Zhao M, Loh JT, Ng SW, Chen Q, Xiao F, Huang En, Ko K, Huang Z, Li J, Kok K, Lu G, Liu X, Lam KP, Liu W, Zhang Y, Yuen K, Mak TW, Lu L. Host-derived lipids orchestrate pulmonary gd T cell response to provide early protection against influenza virus infection. Nat. Commun. 12, 1914(2021). Https://doi.org/10.1038/s41467-021-22242-9

  • Loh JT*, Teo JKH, Lim HH and Lam KP*. Emerging roles of Downstream of Kinase 3 in cell signaling. Front. Immunol. (2020) 11:566192. doi: 10.3389/fimmu.2020.566192 (*Co-corresponding author)

  • Loh JT, Xu S, Huo JX, Kim SS, Wang Y, Lam KP. Dok3-protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity. J Clin Investigat. (2019) 129:2717-29. doi: 10.1172/jci126341

  • Loh JT, TJF Lim, K Ikumi, T Matoba, B Janela, M Gunawan, T Toyama, M Bunjamin, LG Ng, M Poidinger, A Morita, F Ginhoux, S Yamazaki, KP Lam, IH Su. Ezh2 controls skin tolerance through distinct mechanisms in different subsets of skin dendritic cells. iScience. (2018) 10:23-39. doi: 10.1016/j.isci.2018.11.019

  • Chung HH, Or YZ, Shrestha S, Loh JT, Lim CL, Ong Z, Woo ARE, Su IH, Lin VCL. Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution. Sci Rep. (2017) 7:46485. doi: 10.1038/srep46485

  • Loh JT and Su IH. Post-translational modification-regulated leukocyte adhesion and migration. Oncotarget. (2016) 7(24): 37347-37360. doi: 10.18632/oncotarget.8135

  • Loh JT, Gunawan M, Su IH. Ear inflammation and whole-mount ear staining. Bio-protocol. (2016) 6(20):e1967.

  • Gunawan M*, Venkatesan N*, Loh JT*, Wong JF, Berger H, Neo WH, Li LY, La Win MK, Yau YH, Guo T, See PCE, Yamazaki S, Chin KC, Gingras A, Shochat SG, Ng LG, Sze SK, Ginhoux F, Su IH. The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. Nat. Immunol. (2015) 16:505-516. doi: 10.1038/ni.312 (*co-first author)

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